Metabolomics provide new insight on the metabolism of dietary phytochemicals in rats.
Identifieur interne : 003865 ( Main/Exploration ); précédent : 003864; suivant : 003866Metabolomics provide new insight on the metabolism of dietary phytochemicals in rats.
Auteurs : Anthony Fardet [France] ; Rafael Llorach ; Alexina Orsoni ; Jean-François Martin ; Estelle Pujos-Guillot ; Catherine Lapierre ; Augustin ScalbertSource :
- The Journal of nutrition [ 1541-6100 ] ; 2008.
Descripteurs français
- KwdFr :
- Acides coumariques (métabolisme), Acides coumariques (urine), Animaux (MeSH), Extraits de plantes (composition chimique), Extraits de plantes (métabolisme), Extraits de plantes (urine), Flavonoïdes (métabolisme), Flavonoïdes (urine), Lignine (métabolisme), Lignine (urine), Mâle (MeSH), Métabolisme (MeSH), Phénols (métabolisme), Phénols (urine), Polyphénols (MeSH), Rat Wistar (MeSH), Rats (MeSH), Régime alimentaire (MeSH).
- MESH :
- composition chimique : Extraits de plantes.
- métabolisme : Acides coumariques, Extraits de plantes, Flavonoïdes, Lignine, Phénols.
- urine : Acides coumariques, Extraits de plantes, Flavonoïdes, Lignine, Phénols.
- Animaux, Mâle, Métabolisme, Polyphénols, Rat Wistar, Rats, Régime alimentaire.
English descriptors
- KwdEn :
- Animals (MeSH), Coumaric Acids (metabolism), Coumaric Acids (urine), Diet (MeSH), Flavonoids (metabolism), Flavonoids (urine), Lignin (metabolism), Lignin (urine), Male (MeSH), Metabolism (MeSH), Phenols (metabolism), Phenols (urine), Plant Extracts (chemistry), Plant Extracts (metabolism), Plant Extracts (urine), Polyphenols (MeSH), Rats (MeSH), Rats, Wistar (MeSH).
- MESH :
- chemical , chemistry : Plant Extracts.
- chemical , metabolism : Coumaric Acids, Flavonoids, Lignin, Phenols, Plant Extracts.
- chemical , urine : Coumaric Acids, Flavonoids, Lignin, Phenols, Plant Extracts.
- Animals, Diet, Male, Metabolism, Polyphenols, Rats, Rats, Wistar.
Abstract
Foods of plant origin contain a large number of phytochemicals that may positively affect health. Phytochemicals are largely excreted in urine as metabolites that are formed in host tissues or by the microbiota and constitute a great proportion of the urinary metabolome. The latter can be characterized by a metabolomics approach. In this work, we compared the metabolism of lignins to that of the structurally related ferulic acid (FA) and sinapic acid (SA). Five groups of rats (n = 5) were fed for 2 d a purified diet alone [control (C)] or supplemented with lignin-enriched wheat bran (3% of the diet, wt:wt), poplar wood lignins (0.42%), FA (0.42%), or SA (0.42%). The metabolomes of urine samples collected after 1 and 2 d of supplementation were analyzed by high-resolution MS (liquid chromatography/quadrupole time-of-flight). Comparing metabolic fingerprints by gathering semiquantitative information on several hundreds of metabolites and using multivariate statistical analysis (partial least squares for discriminant analysis) showed the similarity between both lignin-supplemented and C groups and confirmed that lignins are largely inert and not absorbed in the body. One the other hand, metabolic fingerprints of the 2 phenolic acid-supplemented groups were clearly distinct from the C group. Differences between the groups were mainly from nonmetabolized FA and SA and metabolites excreted in urine. Thirteen of them were identified as sulfate esters and glucuronide and glycine conjugates of the same phenolic acids, and of dihydrosinapic, vanillic, and benzoic acids. This study shows that metabolomics allows the identification of new metabolites of phytochemicals and can be used to distinguish individuals fed different phytochemical-containing foods.
DOI: 10.1093/jn/138.7.1282
PubMed: 18567748
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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St-Genès-Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité de Nutrition Humaine, Institut National de la Recherche Agronomique, Centre de Recherche de Clermont-Ferrand/Theix, F-63122 St-Genès-Champanelle</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">St-Genès-Champanelle</settlement></placeName></affiliation></author><author><name sortKey="Llorach, Rafael" sort="Llorach, Rafael" uniqKey="Llorach R" first="Rafael" last="Llorach">Rafael Llorach</name></author><author><name sortKey="Orsoni, Alexina" sort="Orsoni, Alexina" uniqKey="Orsoni A" first="Alexina" last="Orsoni">Alexina Orsoni</name></author><author><name sortKey="Martin, Jean Francois" sort="Martin, Jean Francois" uniqKey="Martin J" first="Jean-François" last="Martin">Jean-François Martin</name></author><author><name sortKey="Pujos Guillot, Estelle" sort="Pujos Guillot, Estelle" uniqKey="Pujos Guillot E" first="Estelle" last="Pujos-Guillot">Estelle Pujos-Guillot</name></author><author><name sortKey="Lapierre, Catherine" sort="Lapierre, Catherine" uniqKey="Lapierre C" first="Catherine" last="Lapierre">Catherine Lapierre</name></author><author><name sortKey="Scalbert, Augustin" sort="Scalbert, Augustin" uniqKey="Scalbert A" first="Augustin" last="Scalbert">Augustin Scalbert</name></author></analytic><series><title level="j">The Journal of nutrition</title><idno type="eISSN">1541-6100</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Coumaric Acids (metabolism)</term><term>Coumaric Acids (urine)</term><term>Diet (MeSH)</term><term>Flavonoids (metabolism)</term><term>Flavonoids (urine)</term><term>Lignin (metabolism)</term><term>Lignin (urine)</term><term>Male (MeSH)</term><term>Metabolism (MeSH)</term><term>Phenols (metabolism)</term><term>Phenols (urine)</term><term>Plant Extracts (chemistry)</term><term>Plant Extracts (metabolism)</term><term>Plant Extracts (urine)</term><term>Polyphenols (MeSH)</term><term>Rats (MeSH)</term><term>Rats, Wistar (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acides coumariques (métabolisme)</term><term>Acides coumariques (urine)</term><term>Animaux (MeSH)</term><term>Extraits de plantes (composition chimique)</term><term>Extraits de plantes (métabolisme)</term><term>Extraits de plantes (urine)</term><term>Flavonoïdes (métabolisme)</term><term>Flavonoïdes (urine)</term><term>Lignine (métabolisme)</term><term>Lignine (urine)</term><term>Mâle (MeSH)</term><term>Métabolisme (MeSH)</term><term>Phénols (métabolisme)</term><term>Phénols (urine)</term><term>Polyphénols (MeSH)</term><term>Rat Wistar (MeSH)</term><term>Rats (MeSH)</term><term>Régime alimentaire (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Coumaric Acids</term><term>Flavonoids</term><term>Lignin</term><term>Phenols</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Coumaric Acids</term><term>Flavonoids</term><term>Lignin</term><term>Phenols</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Extraits de plantes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acides coumariques</term><term>Extraits de plantes</term><term>Flavonoïdes</term><term>Lignine</term><term>Phénols</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>Acides coumariques</term><term>Extraits de plantes</term><term>Flavonoïdes</term><term>Lignine</term><term>Phénols</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Diet</term><term>Male</term><term>Metabolism</term><term>Polyphenols</term><term>Rats</term><term>Rats, Wistar</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Mâle</term><term>Métabolisme</term><term>Polyphénols</term><term>Rat Wistar</term><term>Rats</term><term>Régime alimentaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Foods of plant origin contain a large number of phytochemicals that may positively affect health. Phytochemicals are largely excreted in urine as metabolites that are formed in host tissues or by the microbiota and constitute a great proportion of the urinary metabolome. The latter can be characterized by a metabolomics approach. In this work, we compared the metabolism of lignins to that of the structurally related ferulic acid (FA) and sinapic acid (SA). Five groups of rats (n = 5) were fed for 2 d a purified diet alone [control (C)] or supplemented with lignin-enriched wheat bran (3% of the diet, wt:wt), poplar wood lignins (0.42%), FA (0.42%), or SA (0.42%). The metabolomes of urine samples collected after 1 and 2 d of supplementation were analyzed by high-resolution MS (liquid chromatography/quadrupole time-of-flight). Comparing metabolic fingerprints by gathering semiquantitative information on several hundreds of metabolites and using multivariate statistical analysis (partial least squares for discriminant analysis) showed the similarity between both lignin-supplemented and C groups and confirmed that lignins are largely inert and not absorbed in the body. One the other hand, metabolic fingerprints of the 2 phenolic acid-supplemented groups were clearly distinct from the C group. Differences between the groups were mainly from nonmetabolized FA and SA and metabolites excreted in urine. Thirteen of them were identified as sulfate esters and glucuronide and glycine conjugates of the same phenolic acids, and of dihydrosinapic, vanillic, and benzoic acids. This study shows that metabolomics allows the identification of new metabolites of phytochemicals and can be used to distinguish individuals fed different phytochemical-containing foods.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18567748</PMID><DateCompleted><Year>2008</Year><Month>07</Month><Day>03</Day></DateCompleted><DateRevised><Year>2018</Year><Month>03</Month><Day>30</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1541-6100</ISSN><JournalIssue CitedMedium="Internet"><Volume>138</Volume><Issue>7</Issue><PubDate><Year>2008</Year><Month>Jul</Month></PubDate></JournalIssue><Title>The Journal of nutrition</Title><ISOAbbreviation>J Nutr</ISOAbbreviation></Journal><ArticleTitle>Metabolomics provide new insight on the metabolism of dietary phytochemicals in rats.</ArticleTitle><Pagination><MedlinePgn>1282-7</MedlinePgn></Pagination><Abstract><AbstractText>Foods of plant origin contain a large number of phytochemicals that may positively affect health. Phytochemicals are largely excreted in urine as metabolites that are formed in host tissues or by the microbiota and constitute a great proportion of the urinary metabolome. The latter can be characterized by a metabolomics approach. In this work, we compared the metabolism of lignins to that of the structurally related ferulic acid (FA) and sinapic acid (SA). Five groups of rats (n = 5) were fed for 2 d a purified diet alone [control (C)] or supplemented with lignin-enriched wheat bran (3% of the diet, wt:wt), poplar wood lignins (0.42%), FA (0.42%), or SA (0.42%). The metabolomes of urine samples collected after 1 and 2 d of supplementation were analyzed by high-resolution MS (liquid chromatography/quadrupole time-of-flight). Comparing metabolic fingerprints by gathering semiquantitative information on several hundreds of metabolites and using multivariate statistical analysis (partial least squares for discriminant analysis) showed the similarity between both lignin-supplemented and C groups and confirmed that lignins are largely inert and not absorbed in the body. One the other hand, metabolic fingerprints of the 2 phenolic acid-supplemented groups were clearly distinct from the C group. Differences between the groups were mainly from nonmetabolized FA and SA and metabolites excreted in urine. Thirteen of them were identified as sulfate esters and glucuronide and glycine conjugates of the same phenolic acids, and of dihydrosinapic, vanillic, and benzoic acids. This study shows that metabolomics allows the identification of new metabolites of phytochemicals and can be used to distinguish individuals fed different phytochemical-containing foods.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fardet</LastName><ForeName>Anthony</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Unité de Nutrition Humaine, Institut National de la Recherche Agronomique, Centre de Recherche de Clermont-Ferrand/Theix, F-63122 St-Genès-Champanelle, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Llorach</LastName><ForeName>Rafael</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Orsoni</LastName><ForeName>Alexina</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>Jean-François</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Pujos-Guillot</LastName><ForeName>Estelle</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Lapierre</LastName><ForeName>Catherine</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Scalbert</LastName><ForeName>Augustin</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Nutr</MedlineTA><NlmUniqueID>0404243</NlmUniqueID><ISSNLinking>0022-3166</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003373">Coumaric Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005419">Flavonoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010636">Phenols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D059808">Polyphenols</NameOfSubstance></Chemical><Chemical><RegistryNumber>68A28V6010</RegistryNumber><NameOfSubstance UI="C073734">sinapinic acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>9005-53-2</RegistryNumber><NameOfSubstance UI="D008031">Lignin</NameOfSubstance></Chemical><Chemical><RegistryNumber>AVM951ZWST</RegistryNumber><NameOfSubstance UI="C004999">ferulic acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003373" MajorTopicYN="N">Coumaric Acids</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004032" MajorTopicYN="N">Diet</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005419" MajorTopicYN="N">Flavonoids</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008031" MajorTopicYN="N">Lignin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008660" MajorTopicYN="N">Metabolism</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010636" MajorTopicYN="N">Phenols</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059808" MajorTopicYN="N">Polyphenols</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>6</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>7</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>6</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18567748</ArticleId><ArticleId IdType="pii">138/7/1282</ArticleId><ArticleId IdType="doi">10.1093/jn/138.7.1282</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li></region><settlement><li>St-Genès-Champanelle</li></settlement></list><tree><noCountry><name sortKey="Lapierre, Catherine" sort="Lapierre, Catherine" uniqKey="Lapierre C" first="Catherine" last="Lapierre">Catherine Lapierre</name><name sortKey="Llorach, Rafael" sort="Llorach, Rafael" uniqKey="Llorach R" first="Rafael" last="Llorach">Rafael Llorach</name><name sortKey="Martin, Jean Francois" sort="Martin, Jean Francois" uniqKey="Martin J" first="Jean-François" last="Martin">Jean-François Martin</name><name sortKey="Orsoni, Alexina" sort="Orsoni, Alexina" uniqKey="Orsoni A" first="Alexina" last="Orsoni">Alexina Orsoni</name><name sortKey="Pujos Guillot, Estelle" sort="Pujos Guillot, Estelle" uniqKey="Pujos Guillot E" first="Estelle" last="Pujos-Guillot">Estelle Pujos-Guillot</name><name sortKey="Scalbert, Augustin" sort="Scalbert, Augustin" uniqKey="Scalbert A" first="Augustin" last="Scalbert">Augustin Scalbert</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Fardet, Anthony" sort="Fardet, Anthony" uniqKey="Fardet A" first="Anthony" last="Fardet">Anthony Fardet</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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